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It has to be removed from the brain extracellular fluid through EAATs transporters (the most powerful of the active transporters) present in astrocytes (EAAT1-3), neurons (EAAT3) and at the abluminal side of the BBB (EAAT1-3) and through systems Xc and X G in the luminal membrane

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[31] developed a hydroquinone-induced C57BL/6 mouse model, in which topical application of apigenin increased melanin content in hair follicles by enhancing TYR expression, and promoting melanin synthesis